First Choice Neurology

Dr. Jeffrey Gelblum Talks about Proton Pump Inhibitors and Your Risk of Dementia

Dr. Jeffrey Gelblum, Senior Neurologist at First Choice Neurology educates patients about the risk of dementia and Alzheimer’s disease.

Dr. Gelblum offers bi-weekly Lunch and Learn talks on Facebook LIVE ( about various neurological conditions including Alzheimer’s and dementia. Dr. Gelblum is at the forefront of these diseases and has been involved with several Alzheimer’s and dementia clinical trials, GenoScore testing, lectures, and much more over the years. During his bi-weekly Lunch and Learn discussion yesterday, he educated patients about new research that suggests that there may be a higher risk of dementia for people who take Proton Pump Inhibitors (PPIs), medication for GERD, and acid reflux over several years.

Dr. Gelblum pointed out Proton Pump Inhibitors medications. They include Prilosec (omeprazole*), Nexium (esomeprazole*), Prevacid (lansoprazole*), AcipHex (rabeprazole), and Protonix (pantoprazole). He further stated that PPIs inhibit your stomach from secreting acid. And PPIs are not, and never have been FDA-approved for chronic use. They are for temporary usage, 1-2 weeks.

Proton Pump Inhibitors

Dr. Gelblum said, “The problem with Proton Pump Inhibitors is over the long haul, they can cause neurological dysfunction.” That is the data that was published last week.

Dr. Gelblum then stated, “For those individuals who have been taking Proton Pump Inhibitors for more than 4.5 years, there’s over a 30% risk of dementia.” That’s a frightening fact. He said that those who have been on the PPIs need to be re-evaluated by their gastroenterologist or their primary care physician to see if the need for the Proton Pump Inhibitor outweighs the risk.

What is it about the Proton Pump Inhibitors that can predispose you to dementia? Dr. Gelblum said, “There are a lot of theories about the inhibitors. One of the major theories that play is that Proton Pump Inhibitors may actually interfere with a brain enzyme that breaks down amyloid.

The newly approved Alzheimer’s drugs stop amyloid plaque. PPIs may interfere with the brain process of the natural elimination of amyloid.

If you are concerned about your risk of Alzheimer’s disease, contact Dr. Gelblum or another neurologist at First Choice Neurology. First Choice Neurology is the largest neurology group in the United States with more than 50+ Care Centers in multiple Florida counties and services at 45+ major hospitals.

Dr. Gelblum or one of his colleagues can conduct a thorough neurologic evaluation to see if you are at risk for Alzheimer’s or are suffering from early dementia. And if you are at risk, they can treat the disease with newly FDA-approved Alzheimer’s drugs.

To learn more about Alzheimer’s disease and dementia, visit First Choice Neurology’s website at




*Available over-the-counter (OTC) without a prescription.


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